Hyladerm combines low-, medium-, and high-molecular-weight hyaluronic acids to act across skin layers: high‑MW molecules bind moisture at the surface to reduce TEWL, mid‑MW molecules provide dermal hydration and plumping, while low‑MW fragments help support deeper hydration and interaction with the extracellular matrix. Complementary ceramides and humectants reinforce the lipid barrier, improving moisture retention and skin resiliency over time.